Cordarone (amiodarone HCl) is a member of a new class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams' classification) effects, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride.

Cordarone (amiodarone HCl) is a member of a class of antiarrhythmic drugs with predominantly Class III (Vaughan Williams’ classification) effects, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride.

It increases the action potential duration (repolarization inhibition). Class Ic drugs are more potent antiarrhythmics than either class Ia or class Ib drugs. Class Ic drugs do not block potassium channels directly. Class Ic drugs may organize and slow atrial tachyarrhythmias enough to permit 1:1 AV conduction with marked acceleration of the ventricular response rate.

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Amiodarone is used to help keep the heart beating normally in people with life-threatening heart rhythm disorders of the ventricles (the lower Amiodarone has a long half-life; there is potential for drug interactions to occur for several weeks (or even months) after treatment with it has been stopped. Individual interactants: Amiodarone Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class , amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. Abstract.

Because these adverse effects are more likely to occur in patients with a structural heart disorder, class I drugs are not generally recommended for such patients. Class III antiarrhythmic drugs, especially amiodarone (a broad-spectrum antiarrhythmic agent), have gained popularity for use in clinical practice in recent years.

Amiodarone-Digoxin Interaction: Clinical Significance, Time Course of. Development therapy with antiarrhythmic drugs and digitalis in many patients is not 

Philippe Camus  Amiodarone (Cordarone) is an antiarrhythmic medication used to treat ventricular tachycardia or ventricular fibrillation. Includes amiodarone side effects, interactions and indications.

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Amiodarone was initially developed in the early 1960s as a treatment for angina pectoris, since it produces coronary vasodilation and decreases cardiac oxygen demand. However, its pronounced antiarrhythmic effects redirected its use and amiodarone has become a widely used class III anti-arrhythmic drug. Amiodarone is an antiarrhythmic drug with structural similarities to thyroxine. It exhibits all four of the classic Vaughan Williams mechanisms of action, namely sodium and potassium channel blockade, a mild antisympathetic action and some calcium channel blockade, but it is usually classified as a Class III antiarrhythmic drug (see Table 1).

This ICj« value is similar to reported clinically effective serum concentrations of amiodarone. In contrast to amiodarone, the ICJO values for other class HI drugs (bretylium, sotalol, bethanidine, iV-acetylprocainamide) were much higher Amiodarone is an oral and injectable drug that is used to correct abnormal rhythms of the heart. (It is an antiarrhythmic medication.) Although amiodarone has many side effects, some of which are severe and potentially fatal, it has been successful in treating many arrhythmias when other antiarrhythmic drugs have failed. Amiodarone TRADE NAME: Cordarone, Pacerone CLASS: Antiarrhythmic ACTIONS: Prolongs action potential and refractory period. Slows the sinus rate; Increases PR and QT intervals. Decreases Peripheral vascular resistance. INDICATIONS: Life-threatening cardiac arrhythmias such as ventriculartachycardia and ventricular fibrillation.
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Amiodarone is used to treat certain types of serious (possibly fatal) irregular heartbeat (such as persistent ventricular fibrillation / tachycardia). It is used to restore normal heart rhythm and maintain a regular, steady heartbeat.

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Amiodarone is known as an anti- arrhythmic drug. It works by blocking certain electrical signals in the heart that can cause an irregular heartbeat. Amiodarone is available under the following different brand names: Pacerone, Cordarone, and Nexterone.

Amiodarone, a Class III antiarrhythmic agent, is a CYP3A4 substrate associated with a well-established risk of QT prolongation; although the frequency of torsade de pointes (TdP) is less with amiodarone than with other Class III agents, amiodarone is still associated with a risk of TdP. Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class , amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. 2020-11-09 · Amiodarone belongs to a class of drugs called antiarrhythmics. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Abstract. Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a structure similar to that of thyroid hormones.